This book is an extraordinary and gripping look into a once-sharp mind as it descends towards the terrifying alienation and the inaccessible abyss of memory that circumscribe dementia. Avowed mystery readers may see the end coming, but I myself did not. Despite the mutilation (Amanda's body is found with a few fingers severed, post mortem), this is not a gory or graphic book at all, and I would recommend this book to anyone looking for a good mystery or a good book about a complicated, brilliant, but not always likable woman who somehow is able to keep her head even while she loses her mind.
NB: Mike Katz, my Perseus/PGW sales rep, gave me this ARC back in September 2010 and I fully intended to read it on my October vacation, but then I misplaced the book. It surfaced recently, I read it right away, and it will be published in July 2011. It's been getting lots of great bookseller buzz, starting with Winter Institute and building from there.